What Makes Olivetolic Acid (CAS 491-72-5) So Compelling?
May 18, 2025
Biosynthesis of cannabinoids and structural differences between Δ⁹-THC and CBD. Conversion of olivetolic acid to cannabigerolic acid (CBGA) occurs through the use of aromatic prenyltransferase. CBGA acts as the point of differentiation from which cannabinoid-specific FAD-oxidases (THCA synthase & CBDA synthase) convert CBGA to precursor cannabinoid acids. Subsequent decarboxylation of cannabinoid acids results in active cannabinoids. Δ⁹-THC forms a cyclic ring whereas CBD has a hydroxy group resulting three-dimensional structural differences.1
Biosynthesis pathways of cannabinoid, terpenoids, sterols, and flavonoids2,3,4.
Why Should You Pay Attention to Olivetolic Acid?
Olivetolic Acid (OA) is more than a benzoic acid derivative—it...